Possible KRAZATI® (adagrasib)
SIDE EFFECTS
in Treatment
of Advanced NSCLC

Stomach and intestinal (gastrointestinal) problems. Stomach and intestinal side effects, including nausea, diarrhea, or vomiting, are common with KRAZATI but can also sometimes be severe. KRAZATI can also cause serious stomach and intestinal side effects such as bleeding, obstruction, inflammation of the colon (colitis), and narrowing (stenosis).

• Call your healthcare provider if you develop any of the signs or symptoms of stomach or intestinal problems listed above during treatment with KRAZATI
• Your healthcare provider may prescribe an antidiarrheal medicine or anti-nausea medicine, or other treatment, as needed

Changes in the electrical activity of your heart called QTc prolongation. Certain changes can occur in the electrical activity of your heart during treatment with KRAZATI and can be seen on a test called an electrocardiogram (ECG or EKG). QTc prolongation can increase your risk for irregular heartbeats that can be life-threatening, such as torsades de pointes, and can lead to sudden death.

• You should not take KRAZATI if you have congenital long QT syndrome or if you currently have QTc prolongation
• Before taking KRAZATI, tell your healthcare provider about all of your medical conditions:
  • Your healthcare provider should monitor the electrical activity of your heart and the levels of body salts in your blood (electrolytes)—especially potassium and magnesium—before starting and during treatment with KRAZATI, if you have heart failure, a slow heart rate, abnormal levels of electrolytes in your blood, or if you take a medicine that can prolong the QT interval of your heartbeat
  • Tell your healthcare provider if you feel dizzy, lightheaded, or faint, or if you get abnormal heartbeats during treatment with KRAZATI

Liver problems. Abnormal liver blood test results are common with KRAZATI and can sometimes be severe. Your healthcare provider should do blood tests before starting and during treatment with KRAZATI to check your liver function. Tell your healthcare provider right away if you develop any signs or symptoms of liver problems, including:

• Your skin or white part of your eyes turns yellow (jaundice), dark or “tea-colored” urine, light-colored stools (bowel movements), tiredness or weakness, nausea or vomiting, bleeding or bruising, loss of appetite, pain, aching, or tenderness on the right side of your stomach area (abdomen)

Lung or breathing problems. KRAZATI may cause inflammation of the lungs that can lead to death. Tell your healthcare provider or get emergency medical help right away if you have new or worsening shortness of breath, cough, or fever.

The most common side effects of KRAZATI included:

These are not all the possible side effects of KRAZATI. Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088. You may also report side effects to 1-844-647-2841.

DIARRHEA

• Drinking fluids may help you stay hydrated
• Eating smaller meals with foods that might be easy on your stomach, such as those high in potassium and sodium, may help replace what your body has lost
• Discuss possible treatments for this symptom with your doctor

NAUSEA AND VOMITING

• Drink plenty of fluids—water and clear liquids
• Eat smaller, more frequent meals. Nausea may be worse on an empty stomach
• Pay attention to which foods bother your stomach and try to avoid them (ie, greasy, fried, sweet, or spicy foods)
• Talk to your doctor about taking anti-nausea medicine

TIREDNESS/FATIGUE

• Track your energy level throughout the day, and have it on-hand to discuss with your doctor
• Balance rest and activity, prioritizing your most necessary activities for when you may have the most energy
• Staying hydrated and eating foods high in protein may increase your energy levels
• If feelings/emotions are disturbing your sleep, talk to your doctor about a referral to a specialist

The tips provided here are for informational purposes only and are not meant to replace a physician’s medical advice. Please contact your healthcare team if you are experiencing these side effects and ask your doctor if these tips may be right for you.